PROFIL ASAM LAKTAT PENDERITA DIABETES MELLITUS TERKENDALI (KONTROL) DAN TIDAK TERKENDALI (KONTROL)

Abstract

Lactic acid is an intermediate product of carbohydrate metabolism. Increment of plasma lactic acid level usually correlated with
aerobic metabolism defect which caused by hypoperfusion or hypoxia, that can be happened in DM (Diabetes Mellitus) patients. Diabetes
Mellitus is a risk factor of lactic acidosis. Determination of glycated Hb (HbA1c) is a parameter to monitor the blood glucose. The aim
of this study is to compare the mean lactic acid level between uncontrolled and controlled DM) patients and their correlation between
lactic acid and HbA1c level. The research carried out by cross sectional study which was done at the Clinical Pathology Laboratory of
Sardjito Hospital between September–October 2007. Inclusion criteria of samples were diabetic patients who had HbA1c examination.
Statistical analysis was done by independent t test and Pearson correlation test. Twenty one patients were included in this research.
They were divided into two (2) groups, group I are those who had HbA1c ≤ 7%, they consist of 10 patients, group II are patients who
had HbA1c ≥ 7.1%, they consist 11 patients. The mean of lactic acid of group I was 1.85 mmol/L and group II was 1.74 mmol/L
(p = 0.574). There wasn't any significant correlation between HbA1c level and lactic acid. (r = -0.179, p = 0.437). The mean of lactic
acid level in uncontrolled DM was lower than the controlled one but not significant, and there was no significant correlation between
HbA1c level and lactic acid. It is suggested to continue this study but with larger sample to know the correlation between lactic acid and
HbA1c in DM patients who had metformin therapy.