PERBANDINGAN CYSTATIN C DENGAN PARAMETER UJI FUNGSI GINJAL LAINNYA

Pusparini .

Abstract


The Gold standard for the evaluation of the glomerular filtration rate (GFR) is inulin clearance, but in widespread use is prevented
by several technical difficulties. The most commonly used marker for GFR is serum creatinine alone or in conjunction with 24 hour
urine collection for determination of creatinine clearance, but these marker have several limitation include following: influence of age,
sex, muscle mass on endogenous creatinine production, dietary intake and the difficulties of 24 hour urine collection. Fifty six patient
with chronic renal failure and 53 control had analyze for serum creatinin, creatinine clearance and serum cystatin C. The chronic renal
failure patient aged range from (64 + 14.54) year and the control group aged range from (62.5+ 17.5) year. The proposed of this study
was to compare cystatin C with another parameter for renal function test. The result showed that in control group serum creatinine
and creatinine clearance had influence with age, sex and body mass index, but serum cystatin C was not. The normal value of cystatin
C was (0.85 + 0.13) mg/dL In chronic renal failure group there were significant correlation between level of cystatin C with creatinin
clearance (p = 0.000, r = 0.69). The level of cystatin C increase higher than serum creatinine in patient with low clearance creatinine.
In control group we were determined low creatinine clearance in patient with normal serum creatinine and cystatin C.


Keywords


cystatin C, GFR, creatinine clearance

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DOI: http://dx.doi.org/10.24293/ijcpml.v14i1.919

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