PENENTUAN DEFISIENSI BESI ANEMIA PENYAKIT KRONIS MENGGUNAKAN PERAN INDEKS sTfR-F

Authors

  • Adang Muhammad
  • Osman Sianipar

DOI:

https://doi.org/10.24293/ijcpml.v12i1.833

Keywords:

iron deficiency, chronic disease anemia, sTfR-F index

Abstract

Background: The highest prevalence of nutrition problem due to nutrition deï¬ciency is iron deï¬ciency. Chronic disease anemia often occurs coincide with iron deï¬ciency and both show of low iron serum appearance. Difï¬culty occurs when iron deï¬ciency determined in chronic disease anemia by routine parameters. Bone marrow stainning can indicate iron store, but it is invasive. Therefore it needs another more practical parameter that has higher diagnostic value. Objective: To know the more practical parameter that can determine iron deï¬ciency in chronic disease anemia Discussion: Ferritin serum indicates iron store in the body, whereas transferin receptor indicates functional of iron uptake in the erythrocyte. Changes of ferritin level due to inflammation process are varies. Recent evidence shows different changes of transferin receptor between iron deï¬ciency anemia and those in chronic disease anemia. In chronic disease anemia, receptor transferin level increase but not as high as in those who suffer from pure iron deï¬ciency anemia. Studies on groups of iron deï¬ciency anemia, iron deï¬ciency with acute inflammation, chronic disease anemia and healthy control population showed signiï¬cance differences of receptor transferin among them. sTrF-R index is an index derived from the calculation of transferin receptor level divided by logarithmic of the ferritin level. The usage of sTfR-F index indicates more signiï¬cance difference as compared to transferin receptor. Its sensitivity and speciï¬city increase when it is applied to diagnose iron deï¬ciency in elderly group. Conclusions: sTfR-F index is more sensitive and specific for the determination of iron deficiency in chronic disease anemia

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Submitted

2018-03-13

Accepted

2018-03-13

Published

2018-03-13

How to Cite

[1]
Muhammad, A. and Sianipar, O. 2018. PENENTUAN DEFISIENSI BESI ANEMIA PENYAKIT KRONIS MENGGUNAKAN PERAN INDEKS sTfR-F. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 12, 1 (Mar. 2018), 9–15. DOI:https://doi.org/10.24293/ijcpml.v12i1.833.

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