Differences in Hemoglobin Levels 6 Hours and 24 Hours After Packed Red Cells Transfusion
DOI:
https://doi.org/10.24293/ijcpml.v30i2.2093Keywords:
Non-hematological malignancy, anemia, hemoglobin, transfusion, PRCAbstract
The hemoglobin examination instructed by Dr. Sardjito General Hospital attending doctors was 6 hours after the PRC transfusion. It is recommended that a hemoglobin examination be carried out 24 hours after transfusion to determine the patient's hemoglobin after complete equilibrium occurs. This study aimed to determine the mean increase in Hb levels 6 hours and 24 hours after PRC transfusion and to examine the difference in Hb levels 6 hours and 24 hours after PRC transfusion, respectively, compared with baseline Hb levels in non-hematological malignancy patients. This prospective analytic observational study examined hemoglobin at 6 hours and 24 hours after PRC transfusion. The differential test between delta Hb levels 6 hours after PRC transfusion compared to baseline Hb levels and delta Hb levels 24 hours after PRC transfusion compared to baseline Hb levels were analyzed using paired T-test. There was a statistically significant difference between baseline Hb levels and Hb levels 6 hours after PRC transfusion (p<0.0001) and a statistically significant difference between baseline Hb levels and Hb levels 24 hours after PRC transfusion (p<0.0001). The differential test between delta Hb levels 6 hours after PRC transfusion compared to baseline Hb levels and delta Hb levels 24 hours after PRC transfusion compared to baseline Hb levels obtained a statistically significant difference (p=0.0024). The mean increase in hemoglobin was 1.76+0.78 g/dL 6 hours after PRC transfusion and 1.9+0.78 g/dL 24 hours after PRC transfusion. There were differences in delta Hb levels 6 hours and 24 hours after PRC transfusion, respectively, compared with baseline Hb levels in non-hematological malignancy patients, which were statistically significant but not clinically significant.
Downloads
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, et al. Global cancer ststistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021; 71: 209-249.
Madeddu C, Gramignano G, Kotsonis P, Coghe F, Atzeni V, et al. Microenvironmental M1 tumor-associated macrophage polarization influences cancer-related anemia in advanced ovarian cancer: Key role of interleukin-6. Haematologica, 2018; 103(9): 388-391.
Watkins T, Surowiecka MK, McCullough J. Transfusion indications for patients with cancer. Cancer Control, 2015; 22(1): 38-46.
Ramli NA, Iberahim S, Ismail AAC, Hussin H. Incidence of anemia and Red Blood Cell (RBC) transfusion requirement in breast cancer. Caspian J Intern Med, 2023; 14(2): 237-248.
Ali M, Dort JC, Sauro KM. Preoperative hemoglobin and perioperative blood transfusion in major head and neck surgery: A systematic review and meta-analysis. J Otolaryngol Head Neck Surg, 2023; 52(1): 3.
Enya VE, Orji MLC, Brown BJ. Equilibration time of hemoglobin concentration after packed red blood cell transfusion in children seen in the emergency unit of a tertiary hospital in Southeast Nigeria. Transfus Apher Sci, 2023; 62(4): 103709.
Audu LI, Otuneye AT, Mairami AB, Mshelia LJ, Nwatah VE. Post-transfusion hematocrit equilibration: Timing post-transfusion hematocrit check in neonates at the National Hospital, Abuja, Nigeria. Int J Pediatr, 2015; 2015: 175867.
Karndumri K, Tantiworawit A, Hantrakool S, Fanhchaksai K, Rattarittamrong E, et al. Comparison of hemoglobin and hematocrit levels at 1, 4, and 24 h after red blood cell transfusion. Transfus Apher Sci, 2019; 59(1): 102586.
Pilania RK, Saini SS, Dutta S, Das R, Marwaha N, Kumar P. Factors affecting the efficacy of packed red blood cell transfusion in neonates. Eur J Pediatr, 2017; 176(1): 67-74.
Rosita L, Devita N. Differences in changes of hemoglobin between 6-12 hours and 12-14 hours after transfusion. Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018; 24(2): 108-111.
Connell NT. Transfusion medicine. Prim Care Clin Office Pract, 2016; 43(4): 651-659.
Holopainen LS, Tähtinen HH, Gissler M, Korhonen PE, Ekblad MO. Pre-pregnancy body surface area and risk for gestational diabetes mellitus. Acta Diabetol, 2023; 60(4): 527-534.
Muraki R, Hiraoka A, Nagata K, Nakajima K, Oshita T, et al. Novel method for estimating the total blood volume: The importance of adjustment using the ideal body weight and age for the accurate prediction of haemodilution during cardiopulmonary bypass. Interact Cardiovasc Thorac Surg, 2018; 27(6): 802-807.
Nijst P, Verbrugge FH, Bertrand PB, Martens P, Dupont M, et al. Plasma volume is normal but heterogeneously distributed, and true anemia is highly prevalent in patients with stable heart failure. J Card Fail, 2017; 23(2): 138-144.
Piccin A, Cronin M, Brady R, Sweeney J, Marcheselli L, et al. Transfusion-associated circulatory overload in Ireland: A review of cases reported to the National Haemovigilance Office 2000 to 2010. Transfusion, 2015; 55(6): 1223-1230.
Díaz-Cambronero O, Matoses-Jaén S, García-Claudio N, García-Gregorio N, Molins-Espinosa J. Preoperative management of anemia in oncologic surgery. Rev Esp Anestesiol Reanim, 2015; 62(suppl 1): 45-51.
Lv Y, Lau WY, Li Y, Deng J, Han X, et al. Hypersplenism: History and current status. Exp Ther Med, 2016; 12(4): 2377–2382.
Chakraborty S, Keenportz B, Woodward S, Anderson J, Colan D. Paraneoplastic leukemoid reaction in solid tumors. Am J Clin Oncol, 2015; 38: 326–330.
Brugnara C, Oski FA, Nathan DG. Diagnostic approach to the anemic patient. In: Orkin SH, Fisher DE, Ginsburg D, editors. Nathan and Oski’ s hematology and oncology of infancy and childhood. 8th Ed., Philadelphia, Elsevier, 2015; 293-307.
Rajkomar A, McCulloch CE, Fang MC. The low diagnostic utility of rechecking hemoglobins within 24 hours in hospitalized patients. Am J Med, 2016; 129(11): 1194–1197.
Downloads
Submitted
Accepted
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
