CD64 and I/T Ratio as a Diagnostic Test on Neonatal Sepsis in Banjarmasin
DOI:
https://doi.org/10.24293/ijcpml.v30i2.2077Keywords:
Cluster of differentiation 64, I/T ratio, neonatal sepsisAbstract
Neonatal sepsis remains a major problem in the service and care of neonates. The clinical features of neonatal sepsis are non-specific, which makes it difficult to diagnose. The primary objective of this study was to assess the clinical use of cluster of differentiation 64 as a diagnostic marker of neonatal infection. This research used an analytical observational study. The research subjects consisted of 43 samples of neonates at Ulin Hospital, Banjarmasin who had met the inclusion criteria. The results of the study concluded that there was no significant difference between the I/T ratio and cluster of differentiation 64 values in patients with suspected neonatal sepsis with the gold standard procalcitonin and/or blood culture at Ulin Hospital with p=0.874 for the I/T ratio and p=0.285 for cluster of differentiation 64. The diagnostic test for the I/T ratio with a cut-off of 0.2 showed a sensitivity of 23.8%, specificity of 72.7%, positive predictive value of 45.5%, negative predictive value of 50%, mean of 0.16, and median of 0.11. The results of the cluster of differentiation 64 diagnostic test with a cut-off of 2025 showed a sensitivity of 42.9%, specificity of 72.7%, positive predictive value of 81.8%, negative predictive value of 50%, mean of 2487.93, and median of 1671. There was no significant difference between the I/T ratio and cluster of differentiation 64 values in patients with suspected neonatal sepsis with the gold standard procalcitonin and/or blood culture at Ulin Hospital, Banjarmasin.
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Wulandari A, Martuti S, Kaswadi P. Perkembangan diagnosis sepsis pada anak. Sari Pediatri, 2018; 19(4): 237-244.
Pammi M, Flores A, Versalovic J, Leeflang MM. Molecular assays for the diagnosis of sepsis in neonates. Cochrane Library Journal, 2017; 2(2): 1-100.
Mustarim. Association of gene polymorphism of bacterial permeability-increasing protein Rs4358188, cluster of differentiation 14 Rs2569190, interleukin 18 Rs113463 and matrix metalloproteinase-16 Rs2664349 with neonatal sepsis. Macedonian Journal of Medical Science, 2019; 7(17): 2728-2733.
Wulandari A, Martuti S, Kaswadi P. Perkembangan diagnosis sepsis pada anak. Sari Pediatri, 2018; 19(4): 237-244.
Pammi M, Flores A, Versalovic J, Leeflang MM. Molecular assays for the diagnosis of sepsis in neonates. Cochrane Library Journal, 2017; 2(2): 1-100.
Mustarim. Association of gene polymorphism of bacterial permeability-increasing protein Rs4358188, cluster of differentiation 14 Rs2569190, interleukin 18 Rs113463 and matrix metalloproteinase-16 Rs2664349 with neonatal sepsis. Macedonian Journal of Medical Science, 2019; 7(17): 2728-2733.
Schleier M, Lubig J, Kehl S, Hébert S, Woelfle J, et al. Diagnostic utility of interleukin-6 in early-onset sepsis among term newborns: Impact of maternal risk factors and CRP evaluation. Children Journal, 2024; 11(1): 1-13.
Hisamuddin E, Hisam A, Wahid S, Raza G. Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis. Pakistan Journal of Medical Sciences, 2015; 31(3): 527-531.
Pontrelli G, de Crescenzo F, Buzzetti R, Jenkner A, Balduzzi S, et al. Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: A meta-analysis. BMC Infectious Diseases, 2017; 17(1): 302.
Pratiwi, DIN. Uji diagnostik pemeriksaan CD64 (Cluster of Differentiation 64) pada sepsis neonaturum. Universitas Gadjah Mada, 2020; 78-80.
Sabohi E, Saeed F, Khan RN, Khan MA. Immature to total neutrophil ratio as an early indicator of early neonatal sepsis, Pak J Med Sci, 2019; 35(1): 241–246.
McKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, et al. Neutrophils: need for standardized nomenclature. Frontiers in Immunology, 2021; 12(1): 1-14.
Diakite FLF, Diakite AA, Coulibaly O, Diall H, Bocoum A, et al. Hematological profile of newborns hospitalized for neonatal bacterial infection in the neonatology of the Pediatric Department of Gabriel Toure Teaching Hospital Bamako, Mali. Open Journal of Pediatrics, 2020; 10(1): 1-11.
Jethani S, Bhutani N, Yadav A. Diagnostic utility of combined immature and total neutrophil counts along with C-reactive protein in early detection of neonatal sepsis: A cross-sectional study. Annals of Medicine and Surgery Elsevier Journal, 2022; 77(1): 1-4.
Tiwari N, Kumari P, Sristy, Rani R. Usefulness of immature to total neutrophil ratio (I/T ratio) in the diagnosis of early neonatal sepsis. Journal of Cardiovascular Disease Research, 2022; 13(8): 2881-2885.
Palupi IR, Sugianto P. Accuracy of Meningitis Bacterial Score (MBS) as an indicator in establishing the diagnosis of acute bacterial meningitis in adults. Narra Journal, 2021; 1(3): 1-8.
Tang Z, Qin D, Tao M, Kun Lv, Chen S, et al. Examining the utility of the CD64 index compared with other conventional indices for early diagnosis of neonatal infection. Scientific Reports, 2018; 1-7.
Cui W, Xu Y, Fang H, Tong W, Zhu L, et al. Assessment of continues neutrophil CD64 index measurement for diagnosing sepsis and predicting outcome in a Chinese pediatric intensive care unit: A prospective study. Translational Pediatric Journal, 2021; 10(6): 1-9.
Hashem HE, Masry SA, Mokhtar AM, Ismail EA, Abdelaal NM. Valuable role of neutrophil CD64 and highly sensitive CRP biomarkers for diagnostic, monitoring, and prognostic evaluations of sepsis patients in neonatal ICUs. BioMed Research International, 2020; 1-12.
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