Analysis of Liver Fibrosis Degree with APRI Score and FIB-4 Index on Patients with Non-Alcoholic Fatty Liver Disease

Authors

  • Gillian Elvira Seipalla Hasanuddin University
  • Nurahmi Nurahmi Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Daya Hospital, Makassar
  • Ibrahim Abd Samad Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Ibnu Sina Hospital, Makassar

DOI:

https://doi.org/10.24293/ijcpml.v26i2.1414

Keywords:

Liver fibrosis, APRI score, FIB-4 index

Abstract

Liver fibrosis is the accumulation of Extracellular Matrix Protein (EMP) scar tissue after acute or chronic liver injury. Liver biopsy is the gold standard test for evaluating liver fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). This diagnostic method is invasive, painful, and complicated in rare cases; thus the noninvasive methods such as laboratory tests and radiology had been proposed to assess liver fibrosis in NAFLD and are expected to overcome the limitations of liver biopsy. This method consists of aspartate Aminotransferase to the Platelet Ratio Index (APRI) and fibrosis-4 (FIB-4).This
research was retrospective cross-sectional performed at Dr. Wahidin Sudirohusodo Hospital Makassar involving 63 subjects from January to June 2018. The correlated variables were presented in categorical and numerical data and the Pearson correlation test was used to determine the compatibility of APRI score and FIB-4 index with Fibroscan result in patients with NAFLD. A highly significant positive correlation (p <0.001) was found between APRI score and Fibroscan (correlation value = 45.8%), APRI score and FIB-4 index (correlation value = 91.8%), FIB-4 index and Fibroscan (correlation value = 47.6%). The score of Aminotransferase to platelet ratio index score and FIB-4 index could be an alternative method instead of a liver biopsy to predict the degree of fibrosis in patients with NAFLD.

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Author Biographies

Gillian Elvira Seipalla, Hasanuddin University

Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Dr. Wahidin Sudirohusodo Hospital, Makassar

Nurahmi Nurahmi, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Daya Hospital, Makassar

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Daya Hospital, Makassar

Ibrahim Abd Samad, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Ibnu Sina Hospital, Makassar

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University / Ibnu Sina Hospital, Makassar

References

Ahmet Aslan, et al. Effect of Nonalcoholic Fatty Liver Disease on the Hepatic Vein and Artery. Research Article; 2014.p 1-4

Kareem Hassan, et al. Nonalcoholic Fatty Liver Disease: A Comprehensiv Review of a Growing Epidemic. World Journal of Gastroenterology; 2014. p.12082-101

Elena Buzzetti, Rosa L et al. Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology, Vol.XII; 2015. p 1-4.

Linda Ferrel. Update on Staging of Fibrosis and Cirrhosis. University of California ;2013. p.1-22.

Hind I. Fallatah, Noninvasive Biomarkers of Liver Fibrosis, Advance in Hepatology; 2014. p 1-15.

Thad Wilkins, Altaf Tadkod et al, Nonalcoholic Fatty Liver Disease: Diagnosis and Management. American Family Physician, 2013.p. 35-42.

Surastik Agrawal and Ajay K Duseja. Non-Alcoholic Fatty Liver Disease: East Versus West. Journal of Ccinical and Experimental.Hepatology; 2012 Vol 2. p.122-134.

Mustakin. Analisis Derajat Fibrosis Hati dengan Fibroscan, FIB4 Indeks, King Score, dan APRI Score pada pasien penyakit hepatitis kronis. Departemen Ilmu Patologi Klinik. Universitas Hassanudin. 2015.

Atsushi Nakajima, Yoshio S et al. Non-invasive scoring systems for predicting NASH in Japan: evidence from Japan Study Group of NAFLD, Integrative Molecular Medicine; 2015. p.145-149.

Becker L, Evaluation and Staging of Liver Fibrosis; 2015. p. 1-16.

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Submitted

2018-12-13

Accepted

2019-11-07

Published

2020-03-31

How to Cite

[1]
Seipalla, G.E., Nurahmi, N. and Samad, I.A. 2020. Analysis of Liver Fibrosis Degree with APRI Score and FIB-4 Index on Patients with Non-Alcoholic Fatty Liver Disease. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 26, 2 (Mar. 2020), 158–161. DOI:https://doi.org/10.24293/ijcpml.v26i2.1414.

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