ANALYSIS OF PLATELET COUNT ON FIBROSIS DEGREE IN CHRONIC HEPATITIS B PATIENTS

Hairul Anwar, Mutmainnah Mutmainnah, Ibrahim Abdul Samad

Abstract


Chronic hepatitis B is an infectious liver disease caused by hepatitis B virus that persist for more than 6 months. Fibrosis is a result of fibrogenesis which is the formation of connective tissue (scarring) caused by liver tissue damage. Liver damage will affect the production of thrombopoetin causing disturbances in the balance between destruction and production of platelet resulting in decreased platelet counts. This study was a retrospective cross-sectional study by taking the data from medical records of chronic hepatitis B patients who were tested for complete blood count and fibroScan at the Dr.Wahidin Sudirohusodo Hospital Makassar from January 2014 to July 2016. The result showed a total of 323 chronic B hepatitis patients, 99 with severe fibrosis, 84 with moderate fibrosis and 140 with mild fibrosis. The Spearman correlation test showed a significant correlation between the platelet count and the degree of fibrosis (p <0.001) and showed a positive correlation between both of them with a very strong correlation (r = 0.802). The Kruskal-Wallis test showed a significant difference between platelet count and the degree of fibrosis (p<0.001). The conclusion is that a decreased platelet count is a sign of an increase in the degree of fibrosis in chronic hepatitis B patients. It is suggested to perform another study with larger samples based on the degree of fibrosis.

 


Keywords


Platelet, degree of fibrosis, chronic hepatitis B

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References


Sulaiman AS. Pendekatan Terkini Hepatitis B dan C dalam Praktik Klinis Sehari-hari, Jakarta, Sagung Seto, 2010; 1-16.

PPHI, Hepatitis B, diakses dari http://pphi-online.org diakses pada 5 juli 2015.

Soemohardjo S, Gunawan S. Hepatitis B Kronis dalam Ilmu Penyakit Dalam, Ed ke-6., Jilid II, Jakarta, Interna publishing, 2014; 1963-1971.

PPHI, Sirosis Hati, diakses dari http://pphi-online.org, diakses pada 5 juli 2015.

Soleh D, Arianton, Siswandari. Hubungan APRI terhadap derajat fibrosis pasien penyakit hati kronis. Mandala of Health. 2011; 5(2): 1-7.

Macías J, Camacho A, Von Wichmann MA, Lopes Cortes LF, Ortega E, et al. Prediction of survival and decompensations of cirrhosis among HIV/HCV-co-infected patients: a comparison of liver stiffness versus liver biopsy. 7th IAS Conference on HIV Pathogenesis, Treatment, and Prevention, Kuala Lumpur, World J Gastroenterol, 2013; 18: 2784-2792.

Juliana IM dan Wibawa DN. Korelasi antara derajat penyakit sirosis hati berdasarkan klasifikasi Child–Turcotte-Pugh dengan konsentrasi trombopoietin serum, Jurnal Penyakit Dalam, 2008; 9(1): 23-35.

Tambunan KL. Gangguan Hemostasis Pada Sirosis Hati dalam Buku Ajar Ilmu Penyakit Hati, Ed I., Jakarta, Jayabadi, 2007; 421-427.

Hadi S. Hepatitis Kronis dalam: Gastroenterologi. Ed Ketujuh., Bandung, Penerbit PT Alumni, 2002; 583-607.

Fauzi Achmad. EPIDEMI-Prevalensi Penyakit Hepatitis Kronis di Indonesia. Available at: http://www.depkes.go.id. Februari 2011.

Karasu Z, Tekin F, Ersoz G, Gunsar F, Batur Y, et al. Liver Fibrosis is associated with decreased peripheral platelet count in patients with chronic hepatitis B, and C. PubMed, 2007; 52(6): 1535–1539.

Nwokediuko SC. Quantitative platelet abnormalities in patients with hepatitis B virus-related liver disease, Nigeria, Gastroenterol Res, and Elmer Press, 2009; 344-349.




DOI: http://dx.doi.org/10.24293/ijcpml.v24i2.1318

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