IMMATURE PLATELET FRACTION DI DEMAM DENGUE DAN DEMAM BERDARAH DENGUE (Immature Platelet Fraction in Dengue Fever and Dengue Hemorrhagic Fever)

Abstract

Thrombocytopenia is a hematological abnormality found in the majority of Dengue Virus Infection cases with manifestations such
as Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF). Bone marrow response to the decrease in platelets is by increasing
thrombopoiesis which can be identified by Immature Platelet Fraction (IPF) examination as an indirect indicator of bone marrow response
to thrombocytopenia. The examination of IPF in venous blood was performed on 29 subjects who met the 1997 WHO criteria, carried
out from January until August 2012. The EDTA blood samples were examined twice, on the day of their admittance and two days later,
based on a flowcytometry principle using Sysmex XE-2100. The IPF was derived from the immature platelet ratio against the total number
of platelets (IPF %). The test results were statistically analyzed by using SPSS 20. It was found, that IPF in DHF compared between the
first and the third day of their admittance was statistically significantly different with p = 0.033 compared to DF with p = 0.444. The
Pearson's correlation showed an inverse correlation between IPF and platelets with r = -0.675 and p = 0.01. The statistical analysis
revealed a significant difference in IPF between moderate- and mild-thrombocytopenia on the first and third day of their admittance with
p = 0.014 and 0.001, respectively. Based on this study it can be concluded that IPF can be used to indicate the bone marrow response in
both DF and DHF related to thrombocytopenia.