KENASABAN KADAR 8-HYDROXY-2-DEOXYGUANOSINE (8-OHDG) SERUM DENGAN DERAJAT DEFISIT NEUROLOGIS PADA STROK ISKEMIK {Correlation of Serum 8-Hydroxy-2-Deoxyguanosine (8-OHdG) With Neurological Deficits in Ischemic Stroke}

Abstract

The brain blood flow blockage in ischemic stroke increased oxidative stress and free radicals that cause neurotic cells damage.
Computed Tomography Scanning (CT scan) assesses the brain structural damage but not the brain cells damage quantitatively. A
discrepancy between CT scanand clinical symptoms of ischemic stroke patient is often found. 8-Hydroxy-2-Deoxyguanosine (8-OHdG)
serum concentrationis the result offree radical interaction with the cluster C8guanine bases, was used to assess the degree ofneuron cells
damage, oxidative stress levels. Increase of 8-OHdG serum concentration indicates brain cellsdamage as reflected in the neurological
deficitsby the The National Institutes of Health Stroke Scale (NIHSS). The aim of this study was to know the correlation of 8-OHdG serum
concentration with the determination of the degree of neurological deficitby NIHSS inischemic stroke patients. Seventy-two patients with
acute ischemic stroke were enrolled in the Dr. Hasan Sadikin Hospital from August 2013 to January 2014. The research was carried
out by cross sectional study design. Statistical analysis was performed by Kruskal-Wallis test, rank Spearman's correlation test. Mild
neurological deficit with a median of 8-OHdG serum concentrations was 3.9 ng/mL (3.3−12.0 ng/mL), moderate neurological deficit
was 23 ng/mL (8.0−51.0 ng/mL) and the severe neurological deficit was 77.5 ng/mL (54.0−97.0 ng/mL). The correlation of 8-OHdG
serum concentration with neurological deficits in acute ischemic stroke was 0.912 (p<0.001. Correlation of serum 8-OHdG concentration
with neurological deficits in acute ischemic stroke was 0.912 (p<0.001). Based on this study result it can be concluded, that this research
has a strong meaningful positive correlation of 8-OHdG serum concentration with neurological deficits as examined by NIHSS. In
conclusion, serum 8-OHdG has a strong meaningful positive correlation with neurological deficits. 8-OHdG serum concentration can be
considered to be used to assess discrepancy between CT scan and clinical symptoms as well in health facilities without CT scan.