Analysis of the Relationship between HbA1c and Serum IGF-1 Levels in Patients with T2DM
DOI:
https://doi.org/10.24293/ijcpml.v29i3.2151Keywords:
Type 2 diabetes mellitus, serum IGF-1, HbA1cAbstract
Type 2 Diabetes Mellitus (T2DM) is characterized by the reduced ability of insulin responses, leading to difficulty in processing blood sugar. It is caused by a combination of two main factors: damaged insulin secretion by pancreatic beta-cells and the inability of insulin-sensitive tissues to respond to insulin. Blood sugar monitoring in T2DM is done by measuring glycated hemoglobin or Hemoglobin A1c (HbA1c). Insulin Like Growth Factor-1 (IGF-1) is the primary mediator of growth hormone known to play a pivotal biological role in growth and metabolism. This study aims to analyze the relationship between HbA1c levels and serum IGF-1 levels in T2DM patients. The method used was observational analytic with a cross-sectional design. There were 60 T2DM patients involved as research subjects consisting of 26 males and 34 females. HbA1c examination was carried out using the Boronete Affinity Assay, while IGF-1 examination was performed using the Enzyme-Linked Immunosorbent Assay (ELISA) sandwich method. The statistical analysis results showed that the average value and standard deviation of serum IGF-1 levels in controlled T2DM was higher (5740.23±4320.60 pg/mL) than that of uncontrolled T2DM (4843.18±3375.63 pg/mL), showed no significant difference (p=0.462) and no correlation between HbA1c and serum IGF-1 levels in T2DM subjects (r=-0.005 p=0.972). It was concluded that there was no significant relationship between HbA1c levels and serum IGF-1 levels in patients with T2DM.
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References
Soelistijo, S. Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia. Glob. Initiat. Asthma, 2021; 46.
American Diabeter Assosiation (ADA). Introduction: Standards of medical care in diabetes, 2019; 42.
Sinha B, Ghosal S. A target HbA1c between 7 and 7.7% reduces microvascular and macrovascular events in T2D regardless of duration of diabetes: A meta-analysis of randomized controlled trials. Diabetes Ther, 2021; 12: 1661–1676.
Renes JS, Van Doorn J, Hokken-Koelega ACS. Current insights into the role of the growth hormone-insulin-like growth factor system in short children born small for gestational age. Horm Res Paediatr, 2019; 92(1): 15–27.
Zhang W B, Aleksic S, Gao T, Weiss EF, Demetriou E, Verghese J, et al. Proteins predict all-cause mortality and morbidity in older adults. Cells, 2020; 9(6): 1–18.
Liu F, Wang Y, Zhao Q, Zhang M, Ban B. Association between uric acid and insulin-like growth factor-1 in type 2 diabetes mellitus. Int J Gen Med, 2021; 14: 4017–4023.
Biagetti B, Sim R. GH/IGF-1 abnormalities and muscle impairment: From basic research to clinical practice. Int J Mol Sci, 2021; 22(1): 415.
Aleidi SM, Shayeb E, Bzour J, Abu-rish E, Hudaib M, et al. Serum level of insulin-like growth factor-I in type 2 diabetic patients: Impact of obesity. Horm Mol Biol Clin Investig, 2019; 39(1): 1–8.
Suda K, Masumoto R, Fukuoka H, Iguchi G, Hirota Y, Nishizawa H, et al. The influence of type 2 diabetes on serum GH and IGF-I levels in hospitalized Japanese patients. Growth Horm IGF Res, 2016; 29: 4–10.
Brener A, Sagi L, Shtamler A, Levy S, Fattal-valevski A. Insulin-like growth factor-1 status is associated with insulin resistance in young patients with spinal muscular atrophy. Neuromuscul Disord, 2020; 30(11): 888-896.
Angela T, Ginting CN, Chiuman L, Ginting SF. IGF-1 levels in patients with type 2 diabetes mellitus. Majalah Kedokteran Bandung, 2021; 53(2): 78–82.
Caputo M, Pigni S, Agosti E, Daffara T, Ferrero A, et al. Regulation of GH and GH signaling by nutrients, 2021; 10(6): 1–39.
Aguirre GA, Ita JR, Garza RG, and Castilla-Cortazar I. Insulin-like growth factor-1 deficiency and metabolic syndrome. J Transl Med, 2016; 14(3): 1–24.
Hawkes CP, Grimberg A, Health C. Insulin-like growth factor-I is a marker for the nutritional state. Pediatr Endocrinol Rev, 2015; 13(2): 499–511.
Zhu H, Xu Y, Gong F, Shan G, Yang H, Xu K, Zhang D, et al. Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults. PLoS One, 2017; 12(10): 1–15.
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