THE CORRELATION OF PROCALCITONIN AND MYELOPEROXIDASE INDEX LEVELS IN SEPSIS PATIENTS

Authors

  • Sri Rejeki Wulandari 1Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Airlangga – RSUD Dr.Soetomo Surabaya, Indonesia, Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Airlangga – RSUD Dr.Soetomo Surabaya, Indonesia.
  • Betty Agustina Tambunan Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Airlangga – RSUD Dr.Soetomo Surabaya, Indonesia
  • Paulus Budiono Notopuro Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Airlangga – RSUD Dr.Soetomo Surabaya, Indonesia
  • Hardiono Hardiono Departemen Anestesiologi dan Reanimasi, Fakultas Kedokteran, Universitas Airlangga – RSUD Dr.Soetomo Surabaya, Indonesia

DOI:

https://doi.org/10.24293/ijcpml.v25i3.1451

Keywords:

Sepsis, procalcitonin, MPXI

Abstract

Sepsis masih menjadi masalah utama di dunia. Europan Society of Intensive Care Medicine (ESICM) dan Society of Critical Care Medicine (SCCM) mengikutsertakan quick Sequential Organ Failure Asssessment  (qSOFA) untuk mendiagnosis sepsis. Diperlukan pemeriksaan laboratorium akurat dan cepat selain kultur. Prokalsitonin sebagai penanda spesifik infeksi bakteri. Myeloperoxidase index (MPXI) parameter baru untuk membantu diagnosis sepsis. Penelitian ini bertujuan menganalisis korelasi kadar prokalsitonin dengan MPXI pada pasien sepsis.  Jenis penelitian cross sectional observasional. Pengambilan sampel Desember 2017  – Februari 2018. Subjek penelitian terdiri dari 71 pasien sepsis yang dirawat di Ruang Resusitasi, Ruang Observasi Intensif, dan ruang Intensive Care Unit (ICU) RSUD Dr. Soetomo Surabaya berdasarkan kriteria qSOFA dan SIRS. Pemeriksaan prokalsitonin dengan metode CLIA (ADVIA Centaur XP), MPXI dengan  metode  flowcytometry (ADVIA 2120i) dan kultur menggunakan alat PhoenixTM 100. Kadar prokalsitonin 0,01 ng/mL – 265,16 ng/mL (rerata 16,13 ± 40,91 ng/mL). Nilai MPXI -25,5 – 4,6 (rerata -7,939 ± 4,903). Tidak terdapat korelasi antara kadar prokalsitonin dengan MPXI ( p = 0,604 dan r = - 0,063). Tidak terdapat  korelasi kadar prokalsitonin dengan MPXI pada hasil  kultur positif (p = 0,675, r = 0,072) dan negatif (p = 0,401, r = - 0,147). Kadar prokalsitonin tidak berkolerasi dengan MPXI pada pasien sepsis

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Submitted

2019-01-22

Accepted

2019-04-04

Published

2019-04-13

How to Cite

[1]
Wulandari, S.R., Tambunan, B.A., Notopuro, P.B. and Hardiono, H. 2019. THE CORRELATION OF PROCALCITONIN AND MYELOPEROXIDASE INDEX LEVELS IN SEPSIS PATIENTS. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 25, 3 (Apr. 2019), 358–363. DOI:https://doi.org/10.24293/ijcpml.v25i3.1451.

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