Differences of Vitamin D Levels in Controlled and Uncontrolled Type 2 Diabetes Mellitus Patients

Authors

  • Adhisti Azlin University of North Sumatera
  • Ratna Akbari Ganie University of North Sumatera
  • Santi Syafril University of North Sumatera

DOI:

https://doi.org/10.24293/ijcpml.v26i1.1407

Keywords:

DM type 2, vitamin D, HbA1c

Abstract

Vitamin D as an immunomodulator, plays an important role in controlling glycemic levels and decreasing diabetes complications. HbA1c is a marker of glycemic control which is known to have association with vitamin D. This study aims to see the differences in vitamin D serum levels and glycemic index in patients with type 2 DM.The design of this study is cross-sectional study and it was performed in RSUP HAM in December 2017 until March 2018. DM type 2 patients were classified based on HbA1c <7% controlled and ≥ 7% uncontrolled. Vitamin D serum levels were examined using the Enzyme-Linked Fluourescent Assay (ELFA) method., differences in vitamin D levels among controlled and uncontrolled type 2 diabetes mellitus were assessed by using independent t-test, and the differences of HbA1c level were assessed using Mann-Whitney-U test.45 patients with type 2 DM were divided into controlled (HbA1c <7%) and uncontrolled patients (HbA1c ≥ 7%). There was no difference in vitamin D serum levels between controlled and uncontrolled DM Type 2 patients (p = 0,310).

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Author Biographies

Adhisti Azlin, University of North Sumatera

Department of Clinical Pathology, Faculty Of Medicine, University of North Sumatera

Ratna Akbari Ganie, University of North Sumatera

Department of Clinical Pathology, Faculty Of Medicine, University of North Sumatera

Santi Syafril, University of North Sumatera

Department of Internal Medicine, Faculty of Medicine, University of North Sumatera

References

American Diabetes Association. Classification and Diagnosis of Diabetes. Diabetes Care. 2015, 38(1):S8–S16

World Health Organization. Global Report on Diabetes. 1st ed. Geneva:World Health Organization,2016; pp.21-31.

International Diabetes Federation. IDF Diabetes Atlas. 7th ed. Brussels: International Diabetes Federation,2015; pp.50-53.

Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar. 1st ed. Jakarta: Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI,2013; pp.87-94

International Diabetes Federation. The Global Burden. http://www.idf.org/diabetesatlas/5e/the-global-burden. ( Tanggal akses 15 Agustus 2017 )

Ruslianti. Pengobatan Diabetes Melalui Pola Makan. Jakarta: Kawan Pustaka. 2008

Andi W. Pemeriksaan Laboratorium untuk Diagnosa dan Pengelolaan Diabetes Melitus. Forum Diagnosticum Prodia.1-8. 2009

Sunia GM, Tjokroprawiro A, Martono H. Efek Dixfenfluramine pada Penderita DMTTI-Obesitas. ActaMedica Indonesia vo. XXVIII Suplemen 3. Buku Makalah Lengkap KOPAPDI X 2006; 690. 2006

Acharya A, Halemani S. Role of Vitamin D in Diabetes Melitus. International Journal of Pharmaceutical Sciences And Research 2016; Vol.7 (5) : 1881-1888.

Haryati dan Geria. Hubungan Faktor Resiko Umur, Jenis Kelamin, Kegemukan dan Hipertensi dengan Kejadian Diabetes Melitus Tipe 2 di Wilayah Kerja Puskesmas Mataram. Media Bina Ilmiah.ISSN.2014,Vol 8. 1978-3787

Dunstan DW, Zimmet PZ, Welborn TA, De Courten MP, Cameron AJ, Sicree RA. The rising prevalence of diabetes and impaired glucose tolerance: The Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care. 2002.

Jorde R, Figenschau Y. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr, 2009; 48(6): 349-54.

Luo C, Wong J, Brown M, Hooper M, Molyneaux, Yue D.K. Hypovitaminosis D in Chinese Type 2 Diabetes: Lack of Impact on Clinical Metabolic Status and Biomarkers of Cellular inflammation. Diabetes & Vascular Disease Research, 2009;6(3) 197.

Dhia J, Al timimi, Ardawan F. Serum 25 (OH) D in Diabetes Mellitus type 2 : Relation to Glycaemic Control. Journal of Clinical and Diagnostic Research.2013 Dec, Vol -7 (12): 2686-2688

Palomer X, Gonzales Clemente J, BlancoVaca F. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab, 2008; 10:185-197

Zhang FF, Al Hooti S, Al Zenki S. Vitamin D deficiency is associated with high prevalence of diabetes in Kuwaiti adults: results from a national survey. BMC Public Health, 2016; 16(1): 100

Mitri J, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J ClinNutr, 2011; 65(9): 1005-15.

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Submitted

2018-12-10

Accepted

2019-01-16

Published

2019-11-22

How to Cite

[1]
Azlin, A., Ganie, R.A. and Syafril, S. 2019. Differences of Vitamin D Levels in Controlled and Uncontrolled Type 2 Diabetes Mellitus Patients. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 26, 1 (Nov. 2019), 18–22. DOI:https://doi.org/10.24293/ijcpml.v26i1.1407.

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Articles